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KMID : 0191120220370130100
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Journal of Korean Medical Science
2022 Volume.37 No. 13 p.100 ~ p.100
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Fasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Stroke
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Kim Jun-Yup
Lee Keon-Joo
Kang Ji-Hoon
Kim Beom-Joon
Han Moon-Ku
Kang Kyu-Sik
Park Jong-Moo
Park Tai-Hwan
Park Hong-Kyun
Cho Yong-Jin
Hong Keun-Sik
Lee Kyung-Bok
Jang Myung-Suk
Lee Ji-Sung
Lee June-Young
Bae Hee-Joon
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Abstract
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Background: Clinical implications of elevated fasting triglycerides (FTGs) and non-fasting triglycerides (NFTGs) in acute ischemic stroke (AIS) remain unknown. We aimed to elucidate the correlation and clinical significance of FTG and NFTG levels in AIS patients.
Methods: Using a multicenter prospective stroke registry, we identified AIS patients hospitalized within 24 hours of onset with available NFTG results. The primary outcome was a composite of stroke recurrence, myocardial infarction, and all-cause mortality up to one year.
Results: This study analyzed 2,176 patients. The prevalence of fasting and non-fasting hypertriglyceridemia was 11.5% and 24.6%, respectively. Multivariate analysis revealed that younger age, diabetes, higher body mass index and initial systolic blood pressure were independently associated with both fasting and non-fasting hypertriglyceridemia (all P < 0.05). Patients with higher quartiles of NFTG were more likely to be male, younger, ever-smokers, diabetic, and have family histories of premature coronary heart disease and stroke (all P < 0.05). Similar tendencies were observed for FTG. The composite outcome was not associated with FTG or NFTG quartiles.
Conclusion: The fasting and non-fasting hypertriglyceridemia were prevalent in AIS patients and showed similar clinical characteristics and outcomes. High FTG and NFTG levels were not associated with occurrence of subsequent clinical events up to one year.
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KEYWORD
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Triglycerides, Postprandial, Fasting Triglycerides, Non-fasting Triglycerides, Ischemic Stroke
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